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In the last a long time, the amount of patients referred for allogeneic hematopoietic mobile transplantation has dropped drastically,133 nevertheless the method must be encouraged to youthful/healthy people in whom BCR/BCL2 inhibitor treatment fails, particularly in those with TP53
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forty four In addition, anergic cells Commonly retain a higher susceptibility to apoptosis Except if anti-apoptotic proteins like BCL2 are overexpressed, as is the case for CLL cells.45 In fact, most major therapeutic improvements taking place in the final decade are relevant to the inhibition of BCR and BCL2-mediated signaling.
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